Journal article
Association of Sustained Immunotherapy with Disability Outcomes in Patients with Active Secondary Progressive Multiple Sclerosis
T Kalincik, N Lizak, CB Malpas, S Sharmin, EK Havrdova, D Horakova, G Izquierdo, S Eichau, A Lugaresi, P Duquette, M Girard, A Prat, C Larochelle, M Trojano, F Grand'maison, P Grammond, P Sola, D Ferraro, R Hupperts, R Bergamaschi Show all
JAMA Neurology | AMER MEDICAL ASSOC | Published : 2020
Abstract
Importance: It is unclear whether relapses and disease-modifying therapies are associated with the rate of disability accumulation in patients with secondary progressive multiple sclerosis (SPMS). Objective: To examine the association of relapses with the rate of disability accumulation in patients with SPMS and to assess whether treatment before or during the secondary progressive phase can slow the progression of disability accumulation. Design, Setting, and Participants: In this observational cohort study, patient data were prospectively collected from the MSBase international registry between January 1, 1995, and February 1, 2018. Among 53680 patients in the MSBase registry, 4997 patient..
View full abstract